Strategies in clozapine-resistant schizophrenia: A literature review
نویسندگان
چکیده
منابع مشابه
Pharmacological augmentation strategies for schizophrenia patients with insufficient response to clozapine: a quantitative literature review.
BACKGROUND When schizophrenia patients have insufficient response to clozapine, pharmacological augmentation is often applied. This meta-analysis summarizes available evidence on efficacy of pharmacological augmentation of clozapine treatment in schizophrenia spectrum disorder. METHODS Only double-blind randomized controlled studies were included. Primary outcome measure was total symptom sev...
متن کاملManagement of clozapine-resistant schizophrenia
The incidence of treatment resistance in schizophrenia (failure to respond to antipsychotic therapy) is about 20%. Factors that may contribute to it include non-adherence (non-compliance) to treatment, comorbid conditions and medication side-effects. The National Institute for Clinical Excellence recommends that clozapine be used for schizophrenia resistant to another atypical antipsychotic. He...
متن کاملA False Case of Clozapine-Resistant Schizophrenia
One of the subjects that most concerns physicians is treatment-resistance. About 30%-60% of schizophrenia patients do not respond adequately to antipsychotic treatment and are known as refractory schizophrenia patients. Clozapine has been the drug of choice in such cases. However, approximately 30% of them do not respond to clozapine either. Here, we describe a patient with an initial diagnosis...
متن کاملEfficacy of clozapine in treatment-resistant schizophrenia
The term ‘treatment-resistant schizophrenia’ is broadly used to describe people with a diagnosis of schizophrenia who do not respond adequately to antipsychotic treatment and continue to have residual symptoms and/or poor psychosocial functioning. Although treatment-resistant schizophrenia is a familiar concept, various definitions and criteria have been proposed over the years to define it as ...
متن کاملRole of Clozapine in Treatment-Resistant Schizophrenia
Clozapine is effective for treating positive symptoms in approximately two-thirds of the 30% of patients with schizophrenia whose psychosis is minimally responsive to typical or atypical antipsychotic drugs at ordinary doses. The dose range at which clozapine is effective in treatment-resistant patients is 2–3 times higher than that needed in non-treatment-resistant patients. The onset of effic...
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ژورنال
عنوان ژورنال: Journal of Mental Health and Human Behaviour
سال: 2016
ISSN: 0971-8990
DOI: 10.4103/0971-8990.182096